Molecular insights into the roles of rab proteins in intracellular dynamics and neurodegenerative diseases

S Veleri, P Punnakkal, GL Dunbar, P Maiti - Neuromolecular medicine, 2018 - Springer
… ’ state is triggered by addition or deletion of a phosphate group (… They are key players in
neurotransmitter release. SV … with Rab3A and Rabphilin for synaptic vesicle docking and fusion. …

Loss of laminin‐a4 results in pre‐and postsynaptic modifications at the neuromuscular junction

KK Chand, KM Lee, NA Lavidis… - The FASEB …, 2017 - Wiley Online Library
… not only a decrease in the availability of synaptic vesicles from the … number of docked vesicles
in Rab3A-knockout mice (66), a … ) Rab3a deletion reduces vesicle docking and transmitter

Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A.

AG Koesters, MM Rich, KL Engisch - bioRxiv, 2023 - biorxiv.org
… examined whether deletion of Rab3A (Rab3A-/-) might prevent homeostatic upregulation of
… mEPC amplitude was strongly reduced, and was completely abolished in mice expressing a …

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

M Encarnação, L Espada, C Escrevente… - Journal of Cell …, 2016 - rupress.org
… protein receptors, which mediate vesicle fusion, have also been identified as … mouse
Rab3a resistant to the shRNA used to silence Rab3a. Overexpression of mouse GFP-Rab3a

[HTML][HTML] Similarity and diversity of presynaptic molecules at neuromuscular junctions and central synapses

K Takikawa, H Nishimune - Biomolecules, 2022 - mdpi.com
… and central synapses: 0.147 μm 2 for rat diaphragm NMJs [23]… knockout mice, the number
of docked synaptic vesicles per … these microdeletions identified common deletions in the ELKS …

Molecular regulation of synaptic release

R Jahn, J Boyken - Neuroscience in the 21st Century: From Basic to …, 2022 - Springer
… processing of neuropeptides, removal of membrane) while … Rab3a, Rab3b, Rab3c, and
Rab27b) involved in docking and … Rupture of this diaphragm leads to the opening of a fusion

Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP‐43Q331K transgenic mouse model of amyotrophic lateral sclerosis

KK Chand, KM Lee, JD Lee, H Qiu, EF Willis… - The FASEB …, 2018 - Wiley Online Library
fusion and release of synaptic vesicles within the motor nerve terminal and manifested in
decreased quantal content and reduced … examined evoked transmitter release under conditions …

Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs

OD Bello, AI Cappa, M de Paola, MN Zanetti… - Experimental cell …, 2016 - Elsevier
Rab3A has been involved in transport of synaptic vesicles to … also showed that Rab3A
expression was reduced after 40 min … Rab3A, the Rab participating in synaptic vesicle fusion, one …

Homeostatic plasticity of the mammalian neuromuscular junction

KL Engisch, X Wang, MM Rich - Vertebrate Motoneurons, 2022 - Springer
… of neurotransmitter released via fusion of synaptic vesicles … in mice with a point mutation in
the synaptic vesicle protein … the presynaptic terminal, altering Rab3A function, which triggers …

Presynaptic active zones of mammalian neuromuscular junctions: Nanoarchitecture and selective impairments in aging

Y Badawi, H Nishimune - Neuroscience research, 2018 - Elsevier
… recruitment, docking, and priming of synaptic vesicles. At … efficient neurotransmitter release:
(1) dock and prime synaptic … The consequences of Bassoon and Piccolo deletion from …